Early Life Programming of Vascular Aging and Cardiometabolic Events: The McDonald Lecture 2022

Abstract The early life programming of adult health and disease (Developmental Origins Adult Health Disease; DOHaD) concept has attracted increased attention during recent years. In this review evidence is presented for epidemiological associations between factors (birth weight, prematurity) cardiometabolic traits risk in life. Even if not all studies concur, the general supporting such links. This could be due to either nature or nurture. There state that genetic markers influencing birth weight also importance offspring hypertension coronary heart disease, argument. On other hand, several studies, both historical experimental, have found change maternal dietary intake famine pregnancy may cause permanent changes body composition as well hemodynamic regulation. Taken together, supports strategy preventive child care, starting already preconception period, lowering affected offspring. Further are needed better understand mediating mechanisms, example concerning arterial function, regulation, renal neuroendocrine influences, related development vascular aging (EVA) cardiovascular manifestations.